|
KMID : 0616620010070020265
|
|
Journal of Soonchunhyang Medical College
2001 Volume.7 No. 2 p.265 ~ p.273
|
|
|
Expression of p53 and p21 in Actinic Keratosis, Keratoacanthoma and Bowen's Disease
|
|
조명구/ Cho MK
조현득/ 양승하/ 김의한/ Cho HD/ Yang SH/ Kim EH
|
|
|
Abstract
|
|
|
Background
The function of the p53 protein was known to regulate cell proliferation by inhibiting cells entering S phase. So DNA damaged cell proliferation was inhibited by apoptosis. p21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought to mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 were expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis were important. The authors analyzed immunohistochemical expression of mutant p53 and p21 protein in some skin tumors.
Method
Thirteen cases of actinic keratosis, 7 cases of keratoacanthoma and 8 cases of Bowen's disease were immunohistochemically stained with p53 and p21 monoclonal antibodies.
Results
1. In case of positive p53 protein and negative p21 protein, the expressed p53 protein was suggested as mutant form.
2. Positive expression of p53 protein and p21 protein in prickle cell layer of actinic keratosis and Bowen's disease was suggested that the composing cells of prickle cell layer were transformed into the proliferated cell. The p21 protein expression was suggested to be induced by the p53 independent pathway.
3. Negative expression of p53 protein and p21 protein in prickle cell layer of keratoacanthoma was suggested that the composing cells of prickle cell layer were completely mature cells, so the keratoacanthoma had good prognosis.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|